ADAMS-1 and ADAMS-9, novel markers in endometriosis
| Autor: | Berna Güngörmus, Adnan Adil Hismiogullari, Gürhan Güney, Mine Islimye Taskin |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Metalloproteinase Thrombospondin 030219 obstetrics & reproductive medicine biology business.industry ADAMTS VEGF receptors Cell Endometriosis medicine.disease 03 medical and health sciences 030104 developmental biology 0302 clinical medicine medicine.anatomical_structure Cancer research Disintegrin biology.protein Medicine business |
| Zdroj: | Journal of Endometriosis and Pelvic Pain Disorders. 13:122-126 |
| ISSN: | 2284-0273 2284-0265 |
| DOI: | 10.1177/2284026520987915 |
| Popis: | Objectives: ADAMTS (A Disintegrin And Metalloproteinase with ThromboSpondin repeats) proteinases, which are released outside the cell (soluble) have very critical roles in damage and repair of extracellular matrix (ECM) processes. Our aim was to analyse the ADAMTS-1 and ADAMTS-9 which were the member of the ADAMTS gene family of metalloproteinases that might had been involved in the cytokines-mediated etiopathogenesis of endometriosis. Methods: A case-control study was performed in an university hospital. Thirty-four patient with endometriosis which was defined via laparoscopy and thirty-three healthy female volunteers were recruited in the present study. Serum ADAMTS-1 and ADAMTS-9 and IL-beta (IL-1 β) and vascular endothelial growth factor (VEGF) levels were determined by a human enzyme-linked immunoassay (ELISA) in all subjects. Results: The demographic characteristics of the patients were significantly higher than healthy control group. The IL-1 β and VEGF levels were significantly higher; ADAMTS-1 and ADAMTS-9 levels were significantly lower in the endometriosis patients compared to the controls. We also found a negative correlation between ADAMTS-1, ADAMTS-9, and IL-1 β, VEGF. Conclusion: The results of the study might suggest that ADAMS-1 and ADAMTS-9 have a role in the pathogenesis of the endometriosis. |
| Databáze: | OpenAIRE |
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