Synthesis of Olaparib derivatives and their antitumor activities

Autor:	Xiang-jing Wang, Qingyan Yan, Xian-gui Huang, Yanghui Guo, Jian-jun Wang, Xi-yu Lou, Wen-sheng Xiang, Xuan Yang, Yi-li Ding
Rok vydání:	2013
Předmět:	Antitumor activity endocrine system diseases Chemistry Positive control General Chemistry medicine.disease Olaparib chemistry.chemical_compound Breast cancer Cell culture Cancer research medicine Cancer cell lines skin and connective tissue diseases
Zdroj:	Chemical Research in Chinese Universities. 29:231-235
ISSN:	1005-9040
Popis:	A series of Olaparib derivatives was synthesized, and their structures were confirmed by 1H NMR, MS and elemental analysis. Their antitumor activities on breast cancer susceptbility gene 1/2(BRCA1/2)-deficient cancer cell lines including HCC1937, Capan-1 and MDA-MB-436 were evaluated. The antitumor activity of compound Olaparib-1 was better than the positive control Olaparib in BRCA1-deficient cell line HCC1937.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::5b51f8aa4f8eba167663c414e4951781 https://doi.org/10.1007/s40242-013-2448-5 Zobrazit plný text záznamu Full text from SpringerLink