Inhibition of Experimental Caries in Rats and Humans by Passive Immunization with Surface Protein Antibody of Streptococcus mutans
| Autor: | Kazuko Takada, Takuji Ikemi, Tadashi Ikeda, Takeo Takeuchi, Masatomo Hirasawa |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
medicine.medical_specialty
Materials science Sucrose Enamel paint biology biology.organism_classification Streptococcus mutans Demineralization chemistry.chemical_compound Endocrinology Antigen Immunization chemistry visual_art Internal medicine Immunology visual_art.visual_art_medium medicine biology.protein Antibody Surface protein |
| Zdroj: | JOURNAL OF DENTAL HEALTH. 42:703-708 |
| ISSN: | 0023-2831 |
| Popis: | We studied the inhibitory effects of passive immunization with antibody against Streptococcus mutans surface protein antigen I/II (SAI/II) on experimental dental caries in rats and humans was investigated. The results obtained were as follows. Two groups of rats were infected with S. mutans (c) and fed a modified diet 2000 which contained 50% sucrose and 6% lyophilized normal rabbit serum or 6% lyophilized anti-SAI/II rabbit serum. A significantly lower caries score was observed in rats fed the modified diet 2000 containing anti-SAI/II serum powder as compared with the control rats. In the intraoral cariogenicity test experiment in humans, the enamel slabs set on both sides of the device were immersed in 3% sucrose solution for 10min. outside the mouth. One side of the enamel was treated with normal rabbit serum and the other side was treated with anti-SAI/II rabbit serum, 3 times daily for 2 weeks. The enamel treated with sucrose plus anti-SAI/II serum showed statistically significant lower demineralization, than the enamel treated with sucrose plus normal serum. |
| Databáze: | OpenAIRE |
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