| Popis: |
A study has been made of the effect of histamine H 2 -receptor antagonists on thermal injury in rat bind paws produced by immersion in water at 56°C for 30 seconds. Cimetidine caused dose-dependent suppression of thermal oedema when administered before the injury, and when given after the injury also suppressed thermal oedema if given before the response was complete. Two other histamine H 2 -receptor antagonists, burimamide and metiamide, had similar effects. The suppression of thermal oedema by cimetidine was due to a reduction in both the hyperaemia and increased vascular permeability to albumin caused by injury. Pretreatment with mepyramine, a histamine H 1 -receptor antagonist, with the 5-hydroxytryptamine (5-HT) antagonists, methysergide and 2-bromolysergic acid diethylamide, and with the prostaglandin synthesis inhibitors, indomethacin and aspirin, did not suppress thermal oedema. |
