Estimated cognitive decline in patients with schizophrenia: A multicenter study
| Autor: | Toshiaki Onitsuka, Takefumi Ueno, Kiyoto Kasai, Hironori Kuga, Masaki Fukunaga, Chika Sumiyoshi, Tomiki Sumiyoshi, Yuka Yasuda, Yuto Takebayashi, Yuko Okahisa, Kazuto Oya, Manabu Takaki, Norio Ozaki, Atsuhito Toyomaki, Michiko Fujimoto, Masanori Isobe, Ryota Hashimoto, for Cocoro, Kenichiro Miura, Naohiro Okada, Naoko Kawano, Shuichi Isomura, Naoki Hashimoto, Tohru Ohnuma, Masaki Kato, Haruo Fujino, Osamu Imura, Hidenaga Yamamori |
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| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
Difference score behavioral disciplines and activities 03 medical and health sciences 0302 clinical medicine Borderline intellectual functioning mental disorders Medicine In patient Cognitive decline Psychiatry business.industry General Neuroscience Wechsler Adult Intelligence Scale Cognition General Medicine medicine.disease 030227 psychiatry Psychiatry and Mental health Neurology Multicenter study Schizophrenia Neurology (clinical) business 030217 neurology & neurosurgery Clinical psychology |
| Zdroj: | Psychiatry and Clinical Neurosciences. 71:294-300 |
| ISSN: | 1323-1316 |
| Popis: | Aim Studies have reported that cognitive decline occurs after the onset of schizophrenia despite heterogeneity in cognitive function among patients. The aim of this study was to investigate the degree of estimated cognitive decline in patients with schizophrenia by comparing estimated premorbid intellectual functioning and current intellectual functioning. Methods A total of 446 patients with schizophrenia (228 male, 218 female), consisting of three sample sets obtained from 11 psychiatric facilities, and 686 healthy controls participated in this study. The Wechsler Adult Intelligence Scale-III (WAIS-III) was used to measure the participants’ current full-scale IQ (FSIQ). The premorbid IQ was estimated using the Japanese Adult Reading Test-25. Estimated cognitive decline (difference score) was defined as the difference between the estimated premorbid IQ and the current FSIQ. Results Patients with schizophrenia showed greater estimated cognitive decline, a lower FSIQ, and a lower premorbid IQ compared with the healthy controls. The mean difference score, FSIQ, and estimated premorbid IQ were −16.3, 84.2, and 100.5, respectively, in patients with schizophrenia. Furthermore, 39.7% of the patients had a difference score of 20 points or greater decline. A discriminant analysis showed that the difference score accurately predicted 81.6% of the patients and healthy controls. Conclusion These results show the distribution of difference score in patients with schizophrenia. These findings may contribute to assessing the severity of estimated cognitive decline and identifying patients with schizophrenia who suffer from cognitive decline. |
| Databáze: | OpenAIRE |
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