| Autor: |
A. Jegorov, Karel Ulbrich, Blanka Říhová, L. Fornůsek, Jiří Strohalm, V. Matha, Pavel Rossmann |
| Rok vydání: |
1992 |
| Předmět: |
|
| Zdroj: |
Journal of Controlled Release. 19:25-39 |
| ISSN: |
0168-3659 |
| DOI: |
10.1016/0168-3659(92)90063-w |
| Popis: |
The aim of this study was to test the pharmacological effectiveness of antibody-targeted cyclosporin A. Only free drug is currently available; its administration is accompanied by nephrotoxicity, hepatotoxicity and neurotoxicity which severely limits the treatment. Moreover, due to the high nonspecific binding to a number of tissues, the therapeutic doses are considerably higher than required for the actual treatment. We suggest using antibody-targeted CsA conjugate based on a water-soluble synthetic copolymer of N-(2-hydroxypropyl)methacrylamide to overcome these problems. In this construct the antibody to T lymphocyte subsets (anti-CD3 in human and anti-Thy 1.2 in mouse) is responsible for the specific delivery which limits the drug action to the target tissue. Antibody-targeted CsA effectively inhibits lectin- and alloantigen-induced T cell proliferation and considerably reduces CsA nephrotoxicity. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
