The Sulfonadyns: a class of aryl sulfonamides inhibiting dynamin I GTPase and clathrin mediated endocytosis are anti-seizure in animal models

Autor: Luke R Odell, Nigel C. Jones, Ngoc Chau, Mark J. Robertson, Joseph I Ambrus, Fiona M Deane, Kelly A. Young, Ainslie Whiting, Jing Xue, Kate Prichard, James A. Daniel, Nick N. Gorgani, Terence J O'brien, Phillip J Robinson, Adam McCluskey
Rok vydání: 2023
Předmět:
Zdroj: RSC Medicinal Chemistry.
ISSN: 2632-8682
Popis: We show that dansylcadaverine (1) a known in-cell inhibitor of clathrin mediated endocytosis (CME), moderately inhibits dynamin I (dynI) GTPase activity (IC50 45 μM) and transferrin (Tfn) endocytosis in U2OS...
Databáze: OpenAIRE