Vieillissement moléculaire des protéines
| Autor: | Aurore Desmons, Philippe Gillery, Laëtitia Gorisse, Stéphane Jaisson |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Human organism Protein Carbonylation Oxidation reduction General Medicine Biology medicine.disease General Biochemistry Genetics and Molecular Biology Disease etiology Cell biology 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Post translational 030220 oncology & carcinogenesis Diabetes mellitus Proteins metabolism Protein processing medicine |
| Zdroj: | médecine/sciences. 33:176-182 |
| ISSN: | 1958-5381 0767-0974 |
| Popis: | Protein molecular aging corresponds to all modifications affecting proteins during their biological life, which lead to the alteration of their structural and functional properties. This phenomenon participates in cell and tissue aging and is therefore involved in the aging of human organism. It is also amplified in various chronic diseases such as diabetes mellitus or chronic kidney disease, where it participates in the development of long-term complications. This review aims at describing the main reactions responsible for molecular aging, their impact on protein properties and the parameters which could influence this phenomenon. A general scheme explaining its role in physiopathology is also proposed. |
| Databáze: | OpenAIRE |
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