The Effect of Ethanol Extract of Guava (Psidium guajava L) Leaf on Hypercholesterolemia-Diabetic White Rats Male Induced by High Fat Feed and Streptozotocin

Autor:	Surisna Surisna, Joni Tandi, Franciska Diana Pratiwi, Magfirah Magfirah, Niluh Puspita Dewi
Rok vydání:	2021
Předmět:	White (mutation) Psidium chemistry.chemical_compound Ethanol Chemistry medicine High fat Food science Streptozotocin medicine.drug
Zdroj:	Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal). 7:201-213
ISSN:	2442-8744 2442-7284
Popis:	This study aims to determine the effect of guava (Psidiium guajava L) leaf extract on hypercholesterolemia-diabetic white rats male and the effective dose for reducing cholesterol and blood glucose levels. This study is a laboratory experimental study using 30 rats divided into 6 test animals. the treatment group, each group consisted of 5 rats. Group I was normal control, group II negative control was given Na-CMC suspension, group III as positive control was given simvastatin group IV dose 150 mg / kg BW, group V dose 250 mg / kg BW and group VI dose 350 mg / kg BW. The results showed that the ethanol extract of guava leaves influenced reducing blood glucose levels of male white rats with an effective dose of 250mg / kg BW with an average reduction of 119 mg/dL and effective reducing the cholesterol levels at a dose of 150 mg /kg BW with an average reduction of 28,33 mg/dL.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::5b0e580a62724952610c44560d2397e1 https://doi.org/10.22487/j24428744.2021.v7.i2.15533 Zobrazit plný text záznamu