Effect of antidepressants on glutamatergic autoregulatory presynaptic mechanism in the rat cerebral cortex

Autor:	Prikhozhan Av, Kovalev Gi, Raevskiĭ Ks
Rok vydání:	1990
Předmět:	Chemistry General Medicine Pharmacology Imipramine General Biochemistry Genetics and Molecular Biology Viloxazine Desipramine Moclobemide Autoreceptor medicine Haloperidol Amitriptyline Chlorpromazine Neuroscience medicine.drug
Zdroj:	Bulletin of Experimental Biology and Medicine. 110:1680-1683
ISSN:	1573-8221 0007-4888
Popis:	Amitriptyline, imipramine, desipramine, viloxazine, moclobemide and its derivative, novel antidepressant befol (10(-6)-5 x 10(-4) M) decreased by 12-20% K(+)-stimulated 3H-D-asp release from perfused synaptosomes of rat brain cortex. Glutamic acid diethyl ester (GDEE) (10(-4) M) antagonized the effect of amitriptyline, imipramine, desipramine and befol and reversed the effect of moclobemide and viloxazine. Among neuroleptics studied, only carbidine, which possesses antidepressant activity together with antipsychotic one in clinics, decreased 3H-D-asp release by GDEE-sensitive mechanism. Effect of haloperidol and chlorpromazine was not affected by GDEE. It is concluded that autoregulatory mechanism on the terminals of glutamatergic neurons may be involved in the antidepressant action.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::5b0cda6867590874ae1d4d3c0f8828c0 https://doi.org/10.1007/bf00842595 Zobrazit plný text záznamu Full text from SpringerLink