Three‐dimensional simultaneous brain T 1 , T 2 , and ADC mapping with MR Multitasking
Autor: | Christopher Nguyen, Zixin Deng, Sen Ma, Nader Binesh, Debiao Li, Franklin G. Moser, Nan Wang, Anthony G. Christodoulou, Fei Han |
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Rok vydání: | 2019 |
Předmět: |
Intraclass correlation
Imaging phantom 030218 nuclear medicine & medical imaging Weighting 03 medical and health sciences 0302 clinical medicine Nuclear magnetic resonance Dimension (vector space) Distortion Human multitasking Radiology Nuclear Medicine and imaging Phantom studies Physiological motion 030217 neurology & neurosurgery Mathematics |
Zdroj: | Magnetic Resonance in Medicine. 84:72-88 |
ISSN: | 1522-2594 0740-3194 |
Popis: | Author(s): Ma, Sen; Nguyen, Christopher T; Han, Fei; Wang, Nan; Deng, Zixin; Binesh, Nader; Moser, Franklin G; Christodoulou, Anthony G; Li, Debiao | Abstract: PurposeTo develop a simultaneous T1 , T2 , and ADC mapping method that provides co-registered, distortion-free images and enables multiparametric quantification of 3D brain coverage in a clinically feasible scan time with the MR Multitasking framework.MethodsThe T1 /T2 /diffusionnweighting was generated by a series of T2 preparations and diffusion preparations. The underlying multidimensional image containing 3 spatial dimensions, 1 T1 weighting dimension, 1 T2 -preparation duration dimension, 1 b-value dimension, and 1 diffusion direction dimension was modeled as a 5-way low-rank tensor. A separate real-time low-rank model incorporating time-resolved phase correction was also used to compensate for both inter-shot and intra-shot phase inconsistency induced by physiological motion. The proposed method was validated on both phantom and 16 healthy subjects. The quantification of T1 /T2 /ADC was evaluated for each case. Three post-surgery brain tumor patients were scanned for demonstration of clinical feasibility.ResultsMultitasking T1 /T2 /ADC maps were perfectly co-registered and free from image distortion. Phantom studies showed substantial quantitative agreement ( R2=0.999 ) with reference protocols for T1 /T2 /ADC. In vivo studies showed nonsignificant T1 (P = .248), T2 (P = .97), ADC (P = .328) differences among the frontal, parietal, and occipital regions. Although Multitasking showed significant differences of T1 (P = .03), T2 (P l .001), and ADC (P = .001) biases against the references, the mean bias estimates were small (ΔT1 % l 5%, ΔT2 % l 7%, ΔADC% l 5%), with all intraclass correlation coefficients greater than 0.82 indicating "excellent" agreement. Patient studies showed that Multitasking T1 /T2 /ADC maps were consistent with the clinical qualitative images.ConclusionThe Multitasking approach simultaneously quantifies T1 /T2 /ADC with substantial agreement with the references and is promising for clinical applications. |
Databáze: | OpenAIRE |
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