Three‐dimensional simultaneous brain T 1 , T 2 , and ADC mapping with MR Multitasking

Autor: Christopher Nguyen, Zixin Deng, Sen Ma, Nader Binesh, Debiao Li, Franklin G. Moser, Nan Wang, Anthony G. Christodoulou, Fei Han
Rok vydání: 2019
Předmět:
Zdroj: Magnetic Resonance in Medicine. 84:72-88
ISSN: 1522-2594
0740-3194
Popis: Author(s): Ma, Sen; Nguyen, Christopher T; Han, Fei; Wang, Nan; Deng, Zixin; Binesh, Nader; Moser, Franklin G; Christodoulou, Anthony G; Li, Debiao | Abstract: PurposeTo develop a simultaneous T1 , T2 , and ADC mapping method that provides co-registered, distortion-free images and enables multiparametric quantification of 3D brain coverage in a clinically feasible scan time with the MR Multitasking framework.MethodsThe T1 /T2 /diffusionnweighting was generated by a series of T2 preparations and diffusion preparations. The underlying multidimensional image containing 3 spatial dimensions, 1 T1 weighting dimension, 1 T2 -preparation duration dimension, 1 b-value dimension, and 1 diffusion direction dimension was modeled as a 5-way low-rank tensor. A separate real-time low-rank model incorporating time-resolved phase correction was also used to compensate for both inter-shot and intra-shot phase inconsistency induced by physiological motion. The proposed method was validated on both phantom and 16 healthy subjects. The quantification of T1 /T2 /ADC was evaluated for each case. Three post-surgery brain tumor patients were scanned for demonstration of clinical feasibility.ResultsMultitasking T1 /T2 /ADC maps were perfectly co-registered and free from image distortion. Phantom studies showed substantial quantitative agreement ( R2=0.999 ) with reference protocols for T1 /T2 /ADC. In vivo studies showed nonsignificant T1 (P = .248), T2 (P = .97), ADC (P = .328) differences among the frontal, parietal, and occipital regions. Although Multitasking showed significant differences of T1 (P = .03), T2 (P l .001), and ADC (P = .001) biases against the references, the mean bias estimates were small (ΔT1 % l 5%, ΔT2 % l 7%, ΔADC% l 5%), with all intraclass correlation coefficients greater than 0.82 indicating "excellent" agreement. Patient studies showed that Multitasking T1 /T2 /ADC maps were consistent with the clinical qualitative images.ConclusionThe Multitasking approach simultaneously quantifies T1 /T2 /ADC with substantial agreement with the references and is promising for clinical applications.
Databáze: OpenAIRE
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