AB0378 EFFECT OF RITUXIMAB ON BONE MINERAL DENSITY IN WOMEN WITH RHEUMATOID ARTHRITIS

Autor: O. Dobrovolskaya, N. Demin, N. Toroptsova, A. Sorokina, D. Kusevich, O. Nikitinskaya
Rok vydání: 2022
Předmět:
Zdroj: Annals of the Rheumatic Diseases. 81:1316.1-1316
ISSN: 1468-2060
0003-4967
Popis: ObjectivesTo compare the effect of rituximab (RIT) treatment on bone mineral density (BMD) in women with rheumatoid arthritis (RA) and those with RA without biological therapy.Methods78 women over 40 years with confirmed RA according to ACR/EULAR criteria (2010) were enrolled in the study: 48 patients treated with RIT and methotrexate (RIT+) and 30 women received only methotrexate (RIT-). The patients did not differ in the glucocorticoid therapy duration and cumulative dose. BMD was determined in the lumbar spine, femur neck and total hip using dual energy x-ray absorptiometry (DXA, Hologic 4500A) at baseline and after 1 year. RA activity was evaluated by disease activity score using 28 joint counts and erythrocyte sedimentation rate (DAS28 ESR). Nonparametric statistic tests were performed.ResultsThere were no differences between patients RIT+ and RIT- in age (median - 58 [53; 63] years and 52 [50; 69] years, p>0.05), RA duration (median – 15 [4; 21] year and 9 [3; 11] year, p>0.05) and DAS28 ESR (median – 5.18 [4.35; 6.25] and 5.71 [4.66; 5.94]). The percentage BMD changes from baseline in lumbar spine, femoral neck and total hip were 0.2% [-3.9%; 4.0%], -1.8% [-6.2%; 2.4%] and -0.3% [-3.5%; 4.5%], respectively, in patients RIT+ and -1.0% [-4.9%; 3.3%], -2.5% [-5.8%; -0.4%], -1.7% [-4.3%; 4.2%], respectively, in persons RIT-. There were no differences in BMD changes in the pair matching test both patients RIT+ and RIT-. No correlations between BMD changes with age, RA duration and DAS28 ESR were found.ConclusionRIT had no effect on BMD in women with RA after 1 year therapy. BMD changes were not associated with age, RA duration and disease activity.Disclosure of InterestsNone declared
Databáze: OpenAIRE
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