A New Therapy for Human Endometriosis: The Therapeutic Value of Leukotriene Receptor Antagonist for Endometriosis

Autor:	Masao Sugamata, Tomomi Ihara, Ichiro Uchiide
Rok vydání:	2015
Předmět:	Infertility medicine.medical_specialty Pregnancy Leukotriene receptor business.industry medicine.drug_class media_common.quotation_subject Endometriosis Antagonist Fertility medicine.disease Gastroenterology Endocrinology Apoptosis Estrogen Internal medicine Medicine business media_common
Zdroj:	Open Journal of Obstetrics and Gynecology. :313-318
ISSN:	2160-8806 2160-8792
DOI:	10.4236/ojog.2015.56045
Popis:	Some drugs that regulate estrogen are currently used as therapy for endometriosis. However, these medical treatments have significant side effects and patients who hope to become pregnant cannot overcome infertility. To compare morphological alterations and clinical symptoms, revised American Fertility Society (r-AFS) scores were compared between patients with and without leukotriene receptor antagonist (LTR-A) treatment. LTR-A-treated cases showed significantly decreased r-AFS score. Furthermore, a significant correlation was seen between r-AFS score and LTR-A treatment period. In treated cases, clinical symptoms decreased and some patients achieved pregnancy. Morphologically, lesions in LTR-A-treated cases showed apoptotic fibroblasts and degeneration of collagen fibers. Our findings revealed that LTR-As had significant therapeutic value for the treatment of human endometriosis. Anti-LT therapy appears efficacious not only in the treatment of clinical symptoms and lesions, but also in improving fertility.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::5afc3f38e2c5cc41feaef896c2610a1a https://doi.org/10.4236/ojog.2015.56045 Zobrazit plný text záznamu