Synthesis, Topoisomerase I and II Inhibitory Activity, Cytotoxicity, and Structure-activity Relationship Study of Rigid Analogues of 2,4,6-Trisubstituted Pyridine Containing 5,6-Dihydrobenzo[h]quinoline Moiety

Autor:	Eunyoung Lee, Hoyoung Choi, Pritam Thapa, Youngjoo Kwon, Younghwa Na, Jung Min Nam, Radha Karki, Eun Mi Ha, Eung-Seok Lee, Byeong Seon Jeong
Rok vydání:	2011
Předmět:	chemistry.chemical_classification biology medicine.drug_class Stereochemistry Topoisomerase Quinoline General Chemistry chemistry.chemical_compound Enzyme chemistry medicine biology.protein Structure–activity relationship Moiety Cytotoxicity Topoisomerase inhibitor DNA
Zdroj:	Bulletin of the Korean Chemical Society. 32:303-306
ISSN:	0253-2964
DOI:	10.5012/bkcs.2011.32.1.303
Popis:	DNA topoisomerases are nuclear enzymes that transiently break one or two strands of DNA, passing a single or double stranded DNA through the break and again resealing the breaks which allow to solve various DNA topological problems ge-nerated during vital cellular proce sses such as replication, trans-cription, recombination, repair, chromatin assembly and chromo-some segregation.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::5af9ab962364504254ad996babfc333b https://doi.org/10.5012/bkcs.2011.32.1.303 Zobrazit plný text záznamu