Cardiac innervation and clinical correlates in idiopathic Parkinsonʼs disease
| Autor: | T Tunc, C Akincioglu, M Unlu |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
medicine.medical_specialty
medicine.diagnostic_test business.industry Dysautonomia General Medicine Scintigraphy Surgery Internal medicine Heart rate Catecholamine Cardiology Medicine Heart rate variability Radiology Nuclear Medicine and imaging Electrical conduction system of the heart medicine.symptom Stage (cooking) business Electrocardiography medicine.drug |
| Zdroj: | Nuclear Medicine Communications. 24:267-271 |
| ISSN: | 0143-3636 |
| Popis: | We evaluated the cardiac innervation status of patients with idiopathic Parkinson's disease (IPD), in order to recognize cardiac dysautonomia at an early clinical stage, using I- -iodobenzylguanidine ( I-MIBG) scintigraphy and its relation to other clinical and laboratory parameters. Fourteen patients with IPD at Hoehn-Yahr stage I and 11 age-matched controls were studied. Patients were scored according to the Unified Parkinson's Disease Rating Scale (UPDRS) in aspects of daily life activities, cognitive and emotional status and motor examination. All patients underwent 5 min electrocardiographic recordings in order to assess the heart rate variability. Planar I-MIBG studies at 15 min and 3 h after intravenous injection of 185 MBq were performed. Heart-to-mediastinum (H/M) ratios were calculated. Plasma catecholamine levels were also evaluated. The mean H/M ratios in patients and controls were 1.84+/-0.40 and 2.35+/-0.29, respectively (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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