| Autor: |
Frank E. Ahuekwe, Patrick Omoregie Isibor, Olubukola Oziegbe, Oluwafunmilyo Abosede Ayodele, Yemisi Dorcas Obafemi, Rapheal Ishola, Okanlawon Onagbesan, O. S. Oduleye, Paul Akinniyi Akinduti |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
Open Access Macedonian Journal of Medical Sciences. 9:946-954 |
| ISSN: |
1857-9655 |
| Popis: |
Uncontrolled use of antibiotics has resulted in the emergence of resistant bacteria. It has necessitated the evaluation of antibacterial activities and phylo-diversity of Aloe vera (also called Aloe barbadensis) plants as antimicrobial agent in Nigeria. Biotyped enteric bacilli of 251 strains obtained from fecal samples of patients with various gastro-intestinal complications are profiled for antibiogram. Resistant biotypes were assayed for susceptibility to Aloe vera latex and further evaluated for time-kill kinetics and phylo-diversity. More than 30% of enteric bacilli, including Citrobacter freundii, Escherichia coli and Proteus mirabilis were resistant to cotrimoxazole, ciprofloxacin, and tetracycline respectively at MIC >16 µg/ml (p=0.004). Aloe vera latex significantly inhibited 39.5% resistant enteric biotypes with a significant average reduction of the viable count at 1xMIC and 2xMIC to less than 3.0 Log10CFU/mL after 24 hours. Flavonoids, alkaloids, terpenoids and anthraquinine in anti-enteric sap significantly correlated and regressed with antibacterial activity (p |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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