Toxicity and Immunogenic Properties of Liposomal form of Vipera Libetina Venom

Autor:	Elena B. Romanova, Vladimir P. Torchilin, Nadezda V. Koshkina, David B. Gelashvili
Rok vydání:	1992
Předmět:	Antiserum Liposome Cellular immunity biology Toxin Pharmaceutical Science Venom Pharmacology biology.organism_classification medicine.disease_cause complex mixtures Subcutaneous injection Vipera Immunology Toxicity medicine
Zdroj:	Journal of Liposome Research. 2:205-216
ISSN:	1532-2394 0898-2104
DOI:	10.3109/08982109209018636
Popis:	The incorporation of Vipera libetina venom into liposomes obtained from pure egg phosphatidyl choline by the reverse phase evaporation method decreases its toxicity by 3-fold - in mice LD50 for the native toxin is 2.22 mg/kg body weight and for the liposomal toxin 6.9 mg/kg. Subcutaneous injection of liposomal preparation into mice stimulates the development of cellular immunity and reproduces the reaction of the delayed-type hypersensitivity. It is. also, shown that after a single dose immunization of mice with liposomes containing 1xLD50 dose of the venom, the.titer.of antibodies increases at the early postinfection period and is maintained on high level longer than after the injection of the native venom. Thus, liposom.es can be succesfully used for antiserum production and protective immunization against Vipera libetina venom.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::5aea1b86022a0e7ea3b068bcd88955c9 https://doi.org/10.3109/08982109209018636 Zobrazit plný text záznamu