Stabilization of β-hairpin structures via inter-strand π-π and hydrogen bond interactions in α-, β-, γ-hybrid peptides

Autor:	K. Srinivasa Rao, M. Udaya Kiran, Bharatam Jagadeesh, Tushar Kanti Chakraborty
Rok vydání:	2009
Předmět:	chemistry.chemical_classification Peptidomimetic Stereochemistry Hydrogen bond Organic Chemistry biochemical phenomena metabolism and nutrition Biochemistry Amino acid chemistry.chemical_compound chemistry Furan Drug Discovery Organic chemistry Pyrrole
Zdroj:	Tetrahedron Letters. 50:4350-4353
ISSN:	0040-4039
DOI:	10.1016/j.tetlet.2009.05.024
Popis:	Synthesis and conformational studies of α-, β-, γ-hybrid peptides containing a pyrrole amino acid (Paa, 1 ) and a furan amino acid (Faa, 2 ), namely Boc-β-Phe-Faa- d -Pro-Gly-Paa-β-HGly-Faa-OMe ( 3 ) and Boc-Paa-β-Phe-Faa- d -Pro-Gly-Paa-β-HGly-Faa-OMe ( 4 ), were carried out and they adopt β-hairpin structures stabilized via inter-strand π–π and hydrogen bonding interactions.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::5ae41b6bc6a3aa0cbdf51ffd5518ff93 https://doi.org/10.1016/j.tetlet.2009.05.024 Zobrazit plný text záznamu Full Text from ScienceDirect