Polymorphism of Alcohol Dehydrogenase Gene ADH1B in Eastern Slavic and Iranian-Speaking Populations

Autor:	N. K. Yankovsky, S. A. Borinskaya, M. V. Sokolova, F. Gasemianrodsari, N. R. Kalyina
Rok vydání:	2005
Předmět:	Minor allele frequency Genetics biology Polymorphism (computer science) Genotype biology.protein ADH1B Allele Alcohol tolerance Allele frequency geographic locations Alcohol dehydrogenase
Zdroj:	Russian Journal of Genetics. 41:1291-1294
ISSN:	1608-3369 1022-7954
DOI:	10.1007/s11177-005-0231-5
Popis:	Frequencies of alleles and genotypes for alcohol dehydrogenase gene ADH1B (arg47his polymorphism), associated with alcohol tolerance/sensitivity, were determined. It was demonstrated that the frequency of allele ADH1B*47his, corresponding to atypical alcohol dehydrogenase variant in Russians, Ukrainians, Iranians, and mountain-dwellers of the Pamirs constituted 3, 7, 24, and 22%, respectively. The frequencies established were consistent with the allele frequency distribution pattern among the populations of Eurasia. Russians and Ukrainians were indistinguishable from other European populations relative to the frequency of allele ADH1B*47his, and consequently, relative to specific features of ethanol metabolic pathways. The data obtained provide refinement of the geographic pattern of ADH1B*47his frequency distribution in Eurasia.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::5adda3d3dc4c9165b4f3cfda8808466c https://doi.org/10.1007/s11177-005-0231-5 Zobrazit plný text záznamu Full text from SpringerLink