Flow injection-spectrophotometeric determination of some catecholamine drugs in pharmaceutical preparations via oxidative coupling reaction with p-toluidine and sodium periodate

Autor:	Loay K. Abdulrahman, Mayada H. Al-Qaissy, Anas M. Al-Abachi
Rok vydání:	2005
Předmět:	Detection limit Chromatography Sodium periodate Methyl dopa Biochemistry Analytical Chemistry chemistry.chemical_compound P-toluidine chemistry Catecholamine medicine Environmental Chemistry Oxidative coupling of methane Spectroscopy medicine.drug
Zdroj:	Analytica Chimica Acta. 538:331-335
ISSN:	0003-2670
DOI:	10.1016/j.aca.2005.02.045
Popis:	A new spectrophotometric flow injection method has been established for the determination of some catecholamine drugs (methyl dopa I, dopamine.HCl II and adrenaline III). The method is based on the oxidative coupling reaction of catecholamine with p-toluidine and sodium periodate to form an orange water-soluble dye product that has a maximum absorption at 480 nm. Linearity was observed in the range of 1–50, 2–50 and 5–70, with a limit of detection (S/N = 3) of 0.4, 0.2 and 0.7 μg ml−1 for I–III, respectively. The method was applied successfully to the determination of I–III in pharmaceutical preparations with a good precision and accuracy.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::5add10ca8cfb77d94677920fad20019b https://doi.org/10.1016/j.aca.2005.02.045 Zobrazit plný text záznamu Full Text from ScienceDirect