Appraisal of methods for the study of chemotherapy of cancer in man: Comparative therapeutic trial of nitrogen mustard and triethylene thiophosphoramide
| Autor: | William Regelson, Zubrod Cg, Clyde O. Brindley, Emil Frei, Thomas C. Chalmers, Raul G. Oviedo, Oleg S. Selawry, Ulfar Jonsson, John Gorman, Louis Lasagna, Bruce I. Shnider, G. Lennard Gold, Albert H. Owens, Margarida M. Dederick, Ralph Jones, Bruce Ferguson, James F. Holland, Marvin A. Schneiderman, Jack Colsky |
|---|---|
| Rok vydání: | 1960 |
| Předmět: |
Oncology
medicine.medical_specialty Chemotherapy Lung Epidemiology business.industry Melanoma medicine.medical_treatment Cancer Disease medicine.disease Therapeutic trial Nitrogen mustard Surgery chemistry.chemical_compound medicine.anatomical_structure chemistry Internal medicine medicine business Thiophosphoramide |
| Zdroj: | Journal of Chronic Diseases. 11:7-33 |
| ISSN: | 0021-9681 |
| DOI: | 10.1016/0021-9681(60)90137-5 |
| Popis: | Suggestions are made for the conduct of chemotherapy trials in patients with cancer. Application of the principles involved are illustrated in a comparative study of triethylene thiophosphoramide and nitrogen mustard in cancer of the lung and breast, melanoma, and Hodgkin's disease. Neither drug was appreciably effective in cancer of the lung which had previously been irradiated or in melanoma. In cancer of the lung not previously irradiated and in cancer of the breast, 30 to 50 per cent reduction in tumor size occurred in 10 to 26 per cent of the patients. In Hodgkin's disease certain factors limit the completeness of the comparison, but it is possible to draw the tentative conclusion that thio-TEPA was less active than HN2 (in the doses used) in inducing remissions. The advantages and disadvantages of this type of trial are discussed and several suggestions are made for improved experimental design. |
| Databáze: | OpenAIRE |
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