Synthesis, Antimicrobial, Antioxidant and Docking Study of Novel 2H-1,4-Benzoxazin-3(4H)-One Derivatives
| Autor: | souad Jabbar Lafta, Helen abdalhassan Mhmood, Ahmed Mutanabbi Abdula, Abdul Jabar Khalf Atia, Redha I. H. Al-Bayati |
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| Rok vydání: | 2020 |
| Předmět: |
chemistry.chemical_classification
2-Aminophenol Antioxidant biology Stereochemistry DPPH medicine.medical_treatment 010401 analytical chemistry 04 agricultural and veterinary sciences Hydrazide biology.organism_classification Antimicrobial 040401 food science 01 natural sciences 0104 chemical sciences chemistry.chemical_compound 0404 agricultural biotechnology Enzyme chemistry Docking (molecular) medicine Candida albicans |
| Zdroj: | Egyptian Journal of Chemistry. 63:225-238 |
| ISSN: | 2357-0245 |
| DOI: | 10.21608/ejchem.2019.16920.2030 |
| Popis: | A novel series of 1,4-benzoxazinone derivatives were synthesized and characterized using FT-IR , 1H-NMR, 13C-NMR and Mass spectroscopy. These compounds were in vitro screened against several bacterial species gram positive and gram negative as well as Candida albicans and found exhibiting moderate to potent activity. The antioxidant study was confirmed for the synthesized derivatives against 1,1‐diphenyl‐2‐picryl hydrazyl (DPPH) radical. Docking study for the potent compound 8 against glucosamine-6-phosphate synthase , the target enzyme for the antimicrobial agents was explored to explain the interactions of the discovered hits with in the amino acid residues of the enzyme active side. The docking parameters enhanced the activity of new compound as promising antimicrobial agents. |
| Databáze: | OpenAIRE |
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