Evaluation of components of X-ray irradiated 7-valent pneumococcal conjugate vaccine and pneumococcal vaccine polyvalent and X-ray and gamma-ray irradiated acellular pertussis component of DTaP vaccine products

Autor:	Juan Arciniega, J.C May, L Rey, Chi-Jen Lee
Rok vydání:	2004
Předmět:	Radiation Chemistry Diphtheria Filamentous haemagglutinin adhesin Pertussis toxin medicine.disease complex mixtures Virology Pneumococcal conjugate vaccine Antigen Pneumococcal vaccine medicine Pertactin Conjugate medicine.drug
Zdroj:	Radiation Physics and Chemistry. 71:415-418
ISSN:	0969-806X
DOI:	10.1016/j.radphyschem.2004.03.039
Popis:	Samples of pneumococcal vaccine polyvalent, 7-valent pneumococcal conjugate vaccine, and two different diphtheria and tetanus toxoids and acellular pertussis vaccines adsorbed were irradiated with X-rays and/or gamma-rays (Co-60). Mouse IgG and IgM antibody responses (ELISA) for types 9V, 14, 18C, and 19F pneumococcal polysaccharides and conjugates indicated that the polysaccharides were more tolerant of the radiation than the conjugates. The mouse antibody response for the detoxified pertussis toxin (PT) antigen, filamentous hemagglutinin antigen (FHA), pertactin (PRN), and fimbriae types 2 and 3 (FIM) antigens for the appropriate vaccine type indicated that the antibody response was not significantly changed in the 25 kGy X-ray irradiated vaccines frozen in liquid nitrogen compared to the control vaccine.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::5aca847e0776381290cbc343f0f9b5bf https://doi.org/10.1016/j.radphyschem.2004.03.039 Zobrazit plný text záznamu Full Text from ScienceDirect