Total synthesis of a marine imidazole alkaloid, clathridine A

Autor:	Norio Taguchi, Seikou Nakamura, Kazushi Maeda, Ikuo Kawasaki, Shunsaku Ohta, Naoki Tsuno, Masayuki Yamashita
Rok vydání:	2000
Předmět:	chemistry.chemical_compound Chemistry Alkaloid Organic Chemistry Drug Discovery Condensation Organic chemistry Regioselectivity Total synthesis Imidazole Parabanic acid Biochemistry Clathridine
Zdroj:	Tetrahedron Letters. 41:4623-4627
ISSN:	0040-4039
DOI:	10.1016/s0040-4039(00)00678-x
Popis:	The first total synthesis of clathridine A (8), a marine imidazole alkaloid, was achieved by using a novel regioselective condensation as a key step, in which preclathridine A (2) was treated with 1-methylparabanic acid (11) in the presence of a silylating agent.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::5ab65d33607b4a959a62bbcb93729b61 https://doi.org/10.1016/s0040-4039(00)00678-x Zobrazit plný text záznamu Full Text from ScienceDirect