Decidualization and Endometrial Extracellular Matrix Remodeling
| Autor: | Paulo Alexandre Abrahamsohn, Rodolfo R. Favaro, M. Telma Zorn |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
medicine.medical_specialty
medicine.drug_class Decidua Decidualization Biology Endometrium Cell biology Extracellular matrix Chorioallantoic membrane medicine.anatomical_structure Endocrinology Estrogen Internal medicine embryonic structures medicine Decidual cells Involution (medicine) reproductive and urinary physiology |
| DOI: | 10.1016/b978-0-12-394445-0.00011-4 |
| Popis: | Chapter Summary To support blastocyst implantation and further development of the embryo, the endometrium of mice and humans undergoes a set of processes known as decidualization. Primed by estrogen and progesterone, endometrial fibroblasts transdifferentiate into decidual cells and acquire an epithelial-like phenotype. Decidualization is a remarkably dynamic process, in which cells at different stages of differentiation and of involution coexist in the endometrial stroma. In the mouse, decidualization starts in the antimesometrial wall of endometrium and participates in the formation of the choriovitelline placenta whereas decidualization in the mesometrial wall of the endometrium contributes to the definitive chorioallantoic placenta. Furthermore, orchestrated by ovarian hormones and other mediators, the structure and molecular composition of the endometrial extracellular matrix (ECM) are deeply modified during decidualization. Collectively, the evidence indicates that ECM remodeling is essential to decidualization, and that the decidua is critical for embryo implantation and development. |
| Databáze: | OpenAIRE |
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