Design, Synthesis and Evaluation of Serine Protease Inhibitor Analogues

Autor:	Laila Kamoune, Arnout Voet, Frans Compernolle, Marc De Maeyer, Koen Robeyns, Wim M. De Borggraeve, Constant Gielens, Georges J. Hoornaert, Luc Van Meervelt
Rok vydání:	2007
Předmět:	Serine protease biology Stereochemistry Chemistry Kazal-type serine protease inhibitor domain Organic Chemistry Serine Protease Inhibitors Thrombin Design synthesis Biochemistry medicine biology.protein Enzyme kinetics Physical and Theoretical Chemistry medicine.drug
Zdroj:	European Journal of Organic Chemistry. 2007:2977-2986
ISSN:	1099-0690 1434-193X
DOI:	10.1002/ejoc.200700180
Popis:	Recent efforts in the field of thrombin inhibitor research have focused on the identification of pyrazinone-containing compounds. In this manuscript we describe the synthesis of the new pyrazinones 12-36. All the targets were fully characterised and screened for serine protease inhibition. © Wiley-VCH Verlag GmbH & Co. KGaA, 2007.
Databáze:	OpenAIRE
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