Devenir à long-terme des craniopharyngiomes de l'adulte
| Autor: | M S Sow, Gilles Brassier, N M Baldé, M.M. Diallo, J.-Y. Poirier, Y Lorcy |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
medicine.medical_specialty
medicine.diagnostic_test business.industry Endocrinology Diabetes and Metabolism Magnetic resonance imaging General Medicine University hospital Growth hormone medicine.disease Body weight Craniopharyngioma Surgery Tumor recurrence Endocrinology Tumor progression medicine business Survival analysis |
| Zdroj: | Annales d'Endocrinologie. 68:186-190 |
| ISSN: | 0003-4266 |
| DOI: | 10.1016/j.ando.2007.04.001 |
| Popis: | There is few published series dealing on the long-term outcome of the adult-onset craniopharyngiomas. We report the long term clinical, tomodensitometric and MRI data outcome of 35 (23 woman and 12 men) consecutive adult-onset cured for craniopharyngiomas between 1983 and 2002, and followed-up in Rennes University Hospital. The operation was performed via frontopterional approach in 59% and transphenoidal approach in 41% of cases. Their age at the time of diagnosis was 44.7+/-15.1 years (21-74). The average postoperation follow-up was 7.4+/-7.0 years (0.1-19.1). Recurrence of tumour occurred in 8 patients (25.8%) and a tumor progression in 1 case. The delay of recurrence after initial surgery was 4.1+/-1.3 years (1.4-6.3). Two patients had 5 and 6 years treatment by growth hormone (GH), without tumor recurrence. The observed increase of weight after the surgical cure of craniopharyngiomas concerned 22 patients (63%). The average weight gain was 17.5+/-14.7 kg (1.5-58). In 7 cases (20%) neuropsychological disorders were noted, of which 2 with lost of professional activity. Three patients died. In conclusion the craniopharyngiomas recurrence is frequent and can appear in very prolonged deadlines after the initial surgery. |
| Databáze: | OpenAIRE |
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