Sequential Right and Left Ventricular Assessment in Posttetralogy of Fallot Patients with Significant Pulmonary Regurgitation
Autor: | Marla Kiess, Rekha Raju, Jasmine Grewal, Vishva A. Wijesekera, Jonathon Leipsic, Bruce Precious, Adam J. Berger |
---|---|
Rok vydání: | 2016 |
Předmět: |
medicine.medical_specialty
Population 030204 cardiovascular system & hematology Asymptomatic 03 medical and health sciences 0302 clinical medicine Cardiac magnetic resonance imaging Internal medicine medicine Radiology Nuclear Medicine and imaging 030212 general & internal medicine education Tetralogy of Fallot education.field_of_study Ejection fraction medicine.diagnostic_test business.industry General Medicine Stroke volume medicine.disease medicine.anatomical_structure Pulmonary valve Pediatrics Perinatology and Child Health Cardiology Surgery medicine.symptom Pulmonary Valve Insufficiency Cardiology and Cardiovascular Medicine business |
Zdroj: | Congenital Heart Disease. 11:606-614 |
ISSN: | 1747-079X |
Popis: | Background The natural history of right ventricular (RV) and left ventricular (LV) size and function among adults with tetralogy of Fallot (TOF) repair and hemodynamically significant pulmonary regurgitation (PR) is not known. The main aim of this study was to determine changes in RV and LV size and function over time in an adult population with TOF repair and hemodynamically significant pulmonary regurgitation. Methods Forty patients with repaired TOF and hemodynamically significant PR were included. These patients were identified on the basis of having more than one CMR between January 2008 and 2015. Patients with a prosthetic pulmonary valve or any cardiac intervention between CMR studies were excluded. Rate of progression (ROP) of RV dilation was determined for both indexed right ventricular end-systolic volume (RVESVi) and indexed right ventricular end-diastolic volume (RVEDVi), and calculated as the difference between the last and first volumes divided by the number of years between CMR#1 and CMR#2. Subjects were also divided into two groups based on the distribution of the ROP of RV dilation: Group I—rapid ROP (>50th percentile) and Group II—slower ROP (≤50th percentile). Results The interval between CMR#1 and CMR#2 was 3.9 ± 1.7 years (range 1–8 years). We did find a significant change in RVEDVi and RVESVi over this time period, although the magnitude of change was small. Nine patients (23%) had a reduction in right ventricular ejection fraction (RVEF) by greater than 5%, 13 patients (33%) had an increase in RVEDVi by greater than 10 mL/m2 and seven patients (18%) had an increase in RVESVi by greater than 10 mL/m2. Median ROP for RVEDVi was 1.8 (range −10.4 to 21.8) mL/(m2 year); RVESVi 1.1 (range −5.8 to 24.5) mL/(m2 year) and RVEF −0.5 (range −8 to 4)%/year. Patients with a rapid ROP had significantly larger RV volumes at the time of CMR#1 and lower RVEF as compared to the slow ROP group. There was no overall significant change in LVEDVi, LVESVi, or LVEF over this time period. Conclusions We have demonstrated, in a small population of patients with hemodynamically significant PR, that there is a small increase in RV volumes and decrease in RVEF over a mean 4-year period. We believe it to be reasonable practice to perform CMR at least every 4 years in asymptomatic patients with repaired TOF and hemodynamically significant PR. We found that LV volumes and function remained stable during the study period, suggesting that significant progressive LV changes are less likely to occur over a shorter time period. Our results inform a safe standardized approach to monitoring adults with hemodynamically significant PR post TOF repair and assist in planning allocation of this expensive and limited resource. |
Databáze: | OpenAIRE |
Externí odkaz: |