Vasopressin and oxytocin secretion in response to the consumption of ecstasy in a clubbing population
| Autor: | Katherine J. Aitchison, Adam R. Winstock, D Hartley, Evangelia M. Tsapakis, D Holt, Mary L. Forsling, Kim Wolff |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Pharmacology
Vasopressin medicine.medical_specialty education.field_of_study Oxytocin secretion Population MDMA Plasma osmolality Psychiatry and Mental health Endocrinology Vasopressin secretion Oxytocin Internal medicine mental disorders Urine osmolality medicine Pharmacology (medical) Psychology education medicine.drug |
| Zdroj: | Journal of Psychopharmacology. 20:400-410 |
| ISSN: | 1461-7285 0269-8811 |
| Popis: | Despite the common use of MDMA (ecstasy) in the UK, the mechanism underlying associated potentially fatal cerebral oedema is unclear. We used a new experimental approach working directly with clubbers to perform a study on 30 (17 male) experienced clubbers (mean 6.6 years of clubbing). Pre and post-clubbing measurements were performed to compare plasma levels of pituitary hormones (vasopressin, oxytocin), plasma and urine osmolality, urinary pH, and plasma sodium and urea. Ecstasy consumption was con.rmed by using urinary drug screening preand post-clubbing. MDMA was detected in the urine samples of 17 subjects, three of which tested positive during pre-clubbing tests. Mean plasma vasopressin concentration increased in the MDMA group (1.28 ± 0.29 to 1.43 ± 0.41 pmol/l), but fell in other participants (1.23 ± 0.42 to 1.16 ± 0.0.34 pmol/l). Similarly, mean plasma oxytocin concentrations increased after ingestion of MDMA (2.02 ± 0.29 to 2.43 ± 0.24 pmol/l), but fell in the group that did not use MDMA (2.17 ± 0.36 pmol/l to 1.89 ± 0.37 pmol/l). There was a significant group by time interaction for plasma osmolality and plasma sodium ( p= 0.001 and p= 0.003, respectively) and between change in urinary osmolality ( p< 0.001) and MDMA use, with the pattern of change being consistent with the induction of inappropriate vasopressin secretion (also known as SIADH) by MDMA. This report demonstrates SIADH in ecstasy-using ‘clubbers’, which has important clinical implications. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|