Effects of molsidomine on right ventricular function
| Autor: | Motoyuki Ishiguro, Hitoshi Matsuo, Kenjiro Kanbara, Hiroshi Akanabe, Akira Goto, Sachiro Watanabe, Takahiro Hirano, Michio Arakawa |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Pharmacology
medicine.medical_specialty Molsidomine medicine.diagnostic_test Heart disease business.industry Radionuclide ventriculography Volume Curve medicine.disease Pressure sensor law.invention Surgery chemistry.chemical_compound chemistry law Heart failure Internal medicine medicine Cardiology Pharmacology (medical) business Electrocardiography Gamma camera |
| Zdroj: | Current Therapeutic Research. 52:70-80 |
| ISSN: | 0011-393X |
| DOI: | 10.1016/s0011-393x(05)80438-2 |
| Popis: | Right ventricular (RV) function was evaluated using the pressure-volume relationship derived from electrocardiographic-gated equilibrium radionuclide ventriculography and RV pressure data measured with a Swan-Ganz catheter. Computerized methods were developed to collect data simultaneously from the gamma camera, electrocardiograph, and RV pressure transducer. Such data are rarely obtained by traditional contrast ventriculography. From the pressure curve and volume curve, a pressure-volume loop was generated from which RV work was calculated. This newly developed technique was assessed in five control subjects and 10 patients with advanced congestive heart failure. Despite maintenance of net work, the pressure-volume loop clearly shifted toward the lower left part of the pressure-volume plane in seven patients who had an end-diastolic volume of more than 90 ml after oral administration of the vasodilator molsidomine. |
| Databáze: | OpenAIRE |
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