Neutrophil-Lymphocyte and Neutrophil-Platelet Ratio during covid-19 infection: association with the occurrence of thromboembolic events
| Autor: | Nouira Imen, marzouki safa, Maazaoui Sarra, Hbibech Sonia, Racil Hajer, Chaouch Nawel |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
education.field_of_study business.industry Deep vein Lymphocyte Population Inflammation Retrospective cohort study medicine.disease Gastroenterology Thrombosis Pulmonary embolism medicine.anatomical_structure Internal medicine medicine Platelet medicine.symptom education business human activities |
| Zdroj: | Clinical problems. |
| DOI: | 10.1183/13993003.congress-2021.pa3888 |
| Popis: | Introduction: Covid-19 can cause a state of hypercoagulability that lead to thromboembolic events (TEE). Studies have shown that the neutrophil-lymphocyte ratio (NLR) and the neutrophil-platelet ratio (NPR) are markers of inflammation involved in the prognosis of certain inflammatory pathologies. The aim of our study was to investigate the association between NLR, NPR and (TEE). Methods: It was a retrospective study of 100 patients with confirmed covid-19 who were hospitalized between October 2020 and December 2020.The population was divided into 2 groups: The first group (G1): covid-19 patients without TEE and the second group G1: covid-19 complicated with TEE. Results: Sixty eight patients were included into G1 versus (vs) 32 patients in G2. The mean age was 63 years in G1 vs 53 years in G2. The mean time for occurrence of TEE after covid-19 diagnosis was 10 days. TEE were pulmonary embolism in 27 cases (84%),a deep vein thrombosis in 6 cases (12%) and the association. C - reactive protein was higher in G2 (185.45 mg/L vs 66.23 mg/L; p=0.003). The neutrophil rate was higher in G2 (9890 e/mm3 vs 7200 e/mm3; p=0.005). On the other side, lymphocyte levels were lower in G2 (580 e/mm3 vrs 980 e/mm3; p=0.001)The G2 had a higher NLR (5.6±2.2 vs 3.45±1.1; p=0.01); with a decreased NPR (0.01 vs 0.02) that could be correlated with the severity of the TEE. Conclusion: In multivariate analysis, NLR, NPR and lymphopenia were associated with the occurrence of TEE, further studies are desirable. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|