Characteristics of the Formation of Memories Relating to Fear in Mice with Depression- and Schizophrenia-Like Phenotypes: Effects of Gender and Age
| Autor: | N. I. Dubrovina, T. V. Lipina, M. V. Khrapova |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
business.industry General Neuroscience Physiology medicine.disease Phenotype Associative learning Age and gender 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Schizophrenia Genetic model Medicine Passive avoidance business 030217 neurology & neurosurgery Young male Depression (differential diagnoses) |
| Zdroj: | Neuroscience and Behavioral Physiology. 48:488-495 |
| ISSN: | 1573-899X 0097-0549 |
| Popis: | We report here a comparative analysis of the acquisition of a conditioned passive avoidance reaction in mice of the mutant strains DISC1-Q31L and DISC1-L100P and mice of the control strain C57Bl/6NCr1 and detection of the effects of gender and age on learning. DISC1-L100P mice showed impairments to associative learning to avoid the dangerous dark sector of the apparatus regardless of gender and age. In DISC1-Q31L mice, the fear memory trace formed only in young males. A deficit of aversive learning was demonstrated in old mice of all the strains tested, with identically lower levels of learning ability in female DISC1-Q31L and C57Bl/6NCr1 mice than males. These characteristics of learning avoidance provide an additional argument for regarding DISC1-L100P mice as a genetic model of a schizophrenia-like state and DISC1-Q31L mice as a model of a depression-like state. |
| Databáze: | OpenAIRE |
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