Obstructive Sleep Apnea is Associated with Longitudinal Increases in Amyloid Burden in Elderly Mild Cognitive Impairment Individuals

Autor:	Omonigho M Bubu, Ogie Queen Umasabor-Bubu, Megan Hogan, Amanda Shim, Mukhtar Fahad
Rok vydání:	2019
Předmět:	Obstructive sleep apnea medicine.medical_specialty business.industry Internal medicine Cardiology Medicine Amyloid burden General Medicine business Cognitive impairment medicine.disease nervous system diseases respiratory tract diseases
Zdroj:	American Journal of Undergraduate Research. 15:71-77
ISSN:	2375-8732 1536-4585
DOI:	10.33697/ajur.2019.008
Popis:	Cross sectional analysis has shown an association between Obstructive Sleep Apnea (OSA) severity and Aβ burden using amyloid-PET among Mild Cognitive Impairment (MCI) patients. However, whether OSA accelerates longitudinal increases in amyloid beta (Aβ) burden in MCI patients is presently unclear. Study participants included a total of 798 subjects with a diagnosis of MCI and were a subset of the ADNI cohort (adni.loni.usc.edu). OSA was self-reported and participants were labeled either as OSA+ or OSA−. Aβ burden was determined by florbetapir SUVRs. To test whether OSA is associated with the rate of change in Aβ data longitudinally, multilevel mixed effects linear regression was used to fit the models with randomly varying intercepts and slopes allowing dependence on OSA status. The final model was adjusted for age, sex, body mass index, education, CPAP use status, history of respiratory disease, hypertension, diabetes, and history of cardiovascular disease. A significant variation in the change (slope) in Aβ volumes over time was seen (p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::5a8b7ace7dd46a0c6689a90edb0ebdc3 https://doi.org/10.33697/ajur.2019.008 Zobrazit plný text záznamu