The dipeptidyl peptidase-4 inhibitor teneligliptin reduces kidney damage from hypercholesterolemia in apolipoprotein E-deficient mice
| Autor: | Hongyang Liu, Yan Lu, Shuai Feng, Nan Li, Hui Liu, Mengye Li, Ying Liu, Jing Xing, Huiling Gao, Jinping Liu |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Apolipoprotein E medicine.medical_specialty Normal diet General Chemical Engineering 030204 cardiovascular system & hematology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine Diabetes mellitus medicine Teneligliptin Kidney Creatinine business.industry General Chemistry medicine.disease 030104 developmental biology medicine.anatomical_structure Endocrinology chemistry Biochemistry lipids (amino acids peptides and proteins) business Lipoprotein medicine.drug Kidney disease |
| Zdroj: | RSC Advances. 7:8702-8708 |
| ISSN: | 2046-2069 |
| Popis: | Hypercholesterolemia is a well-established risk factor for kidney injury that can lead to chronic kidney disease (CKD). Many clinic data show that dipeptidyl peptidase-4 (DPP-4) inhibitor is protective against kidney damage in diabetes patients. The goal of this study was to investigate the possible protective effects of teneligliptin against kidney injury in apolipoprotein E knockout (ApoE−/−) mice. Eight-week-old male ApoE−/− mice were randomly divided into the following 3 groups: a control group fed a normal diet (ND group), a group fed a high cholesterol diet (HD group) or a group fed HD mixed with teneligliptin (HD + Tene group). All groups received different treatments for 6 weeks. The metabolic characteristics of total cholesterol (TC), low-density lipoprotein-cholesterol (LDL-c) and creatinine (Cre) were lower in ApoE−/− HD + Tene mice than ApoE−/− HD mice. Oil-red O staining revealed excessive lipid deposition in the kidneys of ApoE−/− HD mice; however, it was significantly suppressed in the ApoE−/− HD + Tene mice. Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) gene and protein expression was lower in the kidney tissue of ApoE−/− HD + Tene mice than ApoE−/− HD mice. These results indicate that teneligliptin may provide a potential therapeutic target for kidney damage from hypercholesterolemia. |
| Databáze: | OpenAIRE |
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