Dinuclear ruthenium(II) polypyridyl complexes: Mechanistic study with biomolecules, DNA/BSA interactions and cytotoxic activity
| Autor: | Milica Medjedović, Ana Simović, Milan M. Milutinović, Laura Senft, Stefan Blagojević, Nevena Milivojević, Biljana Petrović, Dušan Ćoćić |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
chemistry.chemical_classification
Substitution reaction Methionine 010405 organic chemistry Biomolecule chemistry.chemical_element Glutathione 010402 general chemistry 01 natural sciences Medicinal chemistry 0104 chemical sciences Ruthenium Inorganic Chemistry chemistry.chemical_compound chemistry Nucleophile Materials Chemistry Physical and Theoretical Chemistry Spectroscopy DNA |
| Zdroj: | Polyhedron. 178:114334 |
| ISSN: | 0277-5387 |
| Popis: | The substitution reactions of dinuclear Ru(II) polypyridyl complexes, i.e. [{RuCl(bpy)2}2(μ-pzn)][PF6]2 (1) and [{RuCl(phen)2}2(μ-pzn)][PF6]2 (2) (bpy = 2,2′-bipyridine, phen = 1,10-phenanthroline, μ-pzn = pyrazine), with mononucleotide guanosine-5′-monophosphate (5′-GMP) and sulfur-containing nucleophiles, such as l -methionine ( l -Met) and glutathione (GSH) were studied by UV–Vis spectroscopy. The structures of dinuclear Ru(II) complexes 1 and 2 were preserved during the substitution processes and the calculated enthalpies and entropies of activation (ΔH≠ > 0, ΔS≠ |
| Databáze: | OpenAIRE |
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