Total synthesis of methyl l-daunosaminide hydrochloride via chiral 1,3-oxazine

Autor:	Won-Hun Ham, Tian Jin, Seok-Hwi Park, Jin-Seok Kim, Jong-Cheol Kang, Xiangdan Jin, Yu Mu, Chang-Young Oh
Rok vydání:	2014
Předmět:	Chemistry Hydrochloride Organic Chemistry Total synthesis chemistry.chemical_element Carbon-13 NMR Biochemistry Medicinal chemistry Catalysis chemistry.chemical_compound Intramolecular force Drug Discovery Organic chemistry Stereoselectivity Catalytic hydrogenation Palladium
Zdroj:	Tetrahedron. 70:2570-2575
ISSN:	0040-4020
DOI:	10.1016/j.tet.2014.02.033
Popis:	Total synthesis of methyl l -daunosaminide hydrochloride was achieved from readily available l -tyrosine. Key steps in this strategy were palladium(0) catalyzed stereoselective intramolecular oxazine formation and catalytic hydrogenation of oxazine intermediate. This paper reported 1H and 13C NMR data of α- and β-anomer of methyl l -daunosaminide hydrochloride.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::5a699004ec9c016486690b040d13ac24 https://doi.org/10.1016/j.tet.2014.02.033 Zobrazit plný text záznamu Full Text from ScienceDirect