Hyaluronic acid-modified [19F]FDG-conjugated magnetite nanoparticles: in vitro bioaffinities and HPLC analyses in organs
| Autor: | Volkan Yasakci, Vedat Evren, Ozge Kozgus Guldu, Perihan Ünak, Volkan Tekin |
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| Rok vydání: | 2018 |
| Předmět: |
Chemistry
Health Toxicology and Mutagenesis Public Health Environmental and Occupational Health 02 engineering and technology Conjugated system 021001 nanoscience & nanotechnology 010403 inorganic & nuclear chemistry 01 natural sciences Pollution High-performance liquid chromatography 0104 chemical sciences Analytical Chemistry Bioavailability Tetraethyl orthosilicate chemistry.chemical_compound Nuclear Energy and Engineering In vivo Hyaluronic acid Magnetic nanoparticles Radiology Nuclear Medicine and imaging 0210 nano-technology neoplasms Indocyanine green Spectroscopy Nuclear chemistry |
| Zdroj: | Journal of Radioanalytical and Nuclear Chemistry. 318:1973-1989 |
| ISSN: | 1588-2780 0236-5731 |
| Popis: | In this study, we designed and synthesized [19F]FDG-(2-deoxy-2-[fluorine-19]fluoro-d-glucose) conjugated iron oxide magnetic nanoparticles ([19F]FDG-MNPs) for hybrid imaging and hyperthermia treatment. MNPs were synthesized, silica coated, and fabricated with TEOS (tetraethyl orthosilicate). They were then covered with hyaluronic acid (HA) to enhance their bioavailability. The modified MNPs were conjugated with [19F]FDG and optically labeled with ICG (indocyanine green). The in vitro bioaffinities were surveyed in MCF7 and PC3 cell lines. In vivo bioaffinies were determined using Sprague–Dawley rats. |
| Databáze: | OpenAIRE |
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