| Autor: |
N. J. Jacobsen, Nigel Williams, Michael John Owen |
| Rok vydání: |
1999 |
| Předmět: |
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| DOI: |
10.1016/s0921-0709(99)80061-3 |
| Popis: |
Publisher Summary This chapter focuses on finding liability genes for schizophrenia. Concordance rates for schizophrenia are consistently higher in monozygotic (MZ) than in dizygotic (DZ) twins, with proband-wise MZ concordance rates averaging 46% versus DZ rates of about 14%. Research into the molecular genetics of schizophrenia is entering a new phase of optimism. Currently, the main challenge for the field is how to convert tentative and suggestive findings of linkage into confident assignments to well-circumscribed regions of the genome. This is almost involving the analysis of large samples of affected sibling-pairs and of large unrelated patient samples for linkage disequilibrium. A second challenge is the optimization of techniques that allows large samples to be analyzed in a realistic time frame. Finally, methods are also required that allows the high-throughput mutational analysis of many genes within candidate regions. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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