Spontaneous Extinction of Morphine Salivary Conditioned Response in Dog

Autor:	Nathaniel Kleitman, Dorothy Palmer
Rok vydání:	1928
Předmět:	Saliva business.industry Conditioned response Definite period Classical conditioning Unconditioned stimulus General Biochemistry Genetics and Molecular Biology Anesthesia Morphine Medicine Submaxillary gland business Reinforcement medicine.drug
Zdroj:	Experimental Biology and Medicine. 26:168-169
ISSN:	1535-3699 1535-3702
DOI:	10.3181/00379727-26-4199
Popis:	The conditioned response to morphine is developed by placing a dog, with a fistula of the duct of the submaxillary gland, into a stand for a definite period of time daily, and injecting about 30 mgm. of morphine subcutaneously at the end of each period. The injection of morphine, among other effects, produces a flow of saliva. After a few days, placing the dog in the stand is found to act as a conditioned stimulus, salivation starting before the injection of morphine. If, while continuing the daily placing of the dog in the stand, the injections of morphine be stopped, the conditioned response becomes weaker and gradually disappears.1 This has been termed experimental extinction, and, as had been shown by Pavlov and others, it always follows the repeated application of the conditioned stimulus without “reinforcement” by the unconditioned stimulus. The present investigation was undertaken to determine whether the conditioned response to morphine would persist when not experimentally extinguished. After the...
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::5a5fe3ae396c67320360d44419d217c6 https://doi.org/10.3181/00379727-26-4199 Zobrazit plný text záznamu