Inflammasome polymorphisms confer susceptibility to sporadic malignant melanoma

Autor:	Deepti Verma, Peter Söderkvist, Charlotta Enerbäck, Ensieh Farahani, Mats Fredrikson, Inger Rosdahl, Cecilia Bivik, Ingrid Synnerstad
Rok vydání:	2012
Předmět:	integumentary system NLRP1 medicine.medical_treatment Melanoma Interleukin Inflammasome Dermatology Biology Logistic regression medicine.disease Nodular melanoma General Biochemistry Genetics and Molecular Biology Cytokine Oncology Immunology medicine SNP medicine.drug
Zdroj:	Pigment Cell & Melanoma Research. 25:506-513
ISSN:	1755-1471 3582-9419
DOI:	10.1111/j.1755-148x.2012.01008.x
Popis:	Genetic variants of NLRP3 and NLRP1 are known to modulate levels of pro-inflammatory cytokine interleukin (IL)-1 beta. The purpose of this study was to investigate the association of NLRP3/NLRP1 polymorphisms with susceptibility and clinical features of malignant melanoma in a Swedish casecontrol study. Common variants in NLRP3/NLRP1 were investigated in sporadic malignant melanoma patients and healthy controls followed by analysis using logistic regression. NLRP3 variant (rs35829419) was significantly more common in male patients than in controls (OR, 2.22; CI, 1.273.86). Upon stratification, significant association with nodular melanoma was observed (OR, 2.89; CI, 1.336.30), which intensified in male patients (OR 4.03, CI 1.4011.59). The NLRP1 variant (rs12150220) was significantly more common in fair-skinned female patients (OR, 1.85; CI, 1.043.33) and showed strong associations with nodular melanoma (OR, 6.03; CI, 1.3325). Our data suggest that NLRP3/NLRP1 polymorphisms are associated with melanoma susceptibility; these findings warrant validation in other independent populations.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::5a58c3c9656f3bf80776826af8137948 https://doi.org/10.1111/j.1755-148x.2012.01008.x Zobrazit plný text záznamu Plný text ve formátu PDF