Effect of hematocrit on dialyzer urea and creatinine clearance indices in a hemodialysis patient with erythrocytosis
| Autor: | M C Saddler, Nwosu Ac, Antonios H. Tzamaloukas, Glen H. Murata, Malhotra D |
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| Rok vydání: | 1994 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Urea reduction ratio 030232 urology & nephrology Biomedical Engineering Urology Medicine (miscellaneous) Renal function Bioengineering 030204 cardiovascular system & hematology Hematocrit Biomaterials 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Dry weight hemic and lymphatic diseases medicine Urea clearance medicine.diagnostic_test business.industry General Medicine Stepwise regression chemistry Urea Hemodialysis business circulatory and respiratory physiology |
| Zdroj: | The International Journal of Artificial Organs. 17:591-594 |
| ISSN: | 1724-6040 0391-3988 |
| Popis: | The association between azotemic index dialyzer clearances and hematocrit was investigated in a 63-year-old dialysis-dependent man with acquired renal cysts. During 43 months of hemodialysis, hematocrit rose from 27.3 to 65.0 vol%, as a consequence of high serum erythropoietin levels. Concomitantly, dry weight also increased from 116.8 to 140.8 kg. Both hematocrit and dry weight correlated with: (a) urea reduction ratio, (b) creatinine reduction ratio (CRR), and (c) KT/V urea. All correlations were negative. Stepwise regression showed that only hematocrit was an independent correlate of the CRR (CRR = 0.662 - 007∗ Hct, R2= 0.770); whereas, both hematocrit (Hct) and weight (W) were independent correlates of KT/V urea (KT/V = 2.070 - 0.005∗Hct - 0.009∗W, R2= 0.721). In addition to creatinine clearance, urea clearance through the dialyzer is reduced by a rising hematocrit. The effect of hematocrit on urea clearance is relatively small. Therefore, it requires large changes in hematocrit in order to be detected |
| Databáze: | OpenAIRE |
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