Histological Markers of Solid Cell Nests of the Thyroid

Autor:	Harach Hr
Rok vydání:	1985
Předmět:	endocrine system Pathology medicine.medical_specialty Histology biology Parafollicular cell Thyroid Histogenesis medicine.disease Cytokeratin medicine.anatomical_structure Carcinoembryonic antigen Calcitonin Mucoepidermoid carcinoma Ultimopharyngeal body medicine biology.protein Anatomy
Zdroj:	Cells Tissues Organs. 124:111-116
ISSN:	1422-6421 1422-6405
DOI:	10.1159/000146104
Popis:	It was recently demonstrated that C cells, mucosubstances, and the intermediate filament epidermal keratin are present in solid cell nests (SCN) of the thyroid. The reliability and usefulness of these markers in detecting these ultimobranchial nests have, so far, not been comparatively investigated. In the light of this, a study for the presence of these tracers in SCN at different stages of postnatal life was undertaken. The existence of carcinoembryonic antigen (CEA) in this gut-derived tissue was also searched for. Epidermal keratin was present in the epidermoid-like cells from all SCN studied; calcitonin-immunoreactive C cells and mucosubstances did not always occur. These findings reveal that this cytokeratin would remain as a potential marker to detect and trace back the ultimobranchial tissue component of the thyroid in earlier stages of development. The presence of CEA in practically all SCN surveyed would further support the view that they originate in the gut. This antigen would also be of great value for histological identification of these nests. The usefulness of these markers for the interpretation of the histogenesis of some ultimobranchial-related thyroid neoplastic growths, specifically the medullary and mucoepidermoid carcinomas, is briefly discussed.
Databáze:	OpenAIRE
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