Novel Synthesis of Mafenide and Other Amino Sulfonamides by Electrochemical Reduction of Cyano Sulfonamides

Autor:	Shaik Lateef, Rudraraju Rameshraju, Srinivasulu Reddy Krishna Mohan, Srinivasulu Reddy Jayarama Reddy
Rok vydání:	2006
Předmět:	Nitrile Chemistry Organic Chemistry Inorganic chemistry Electrochemistry Biochemistry Catalysis Cathode Anode law.invention Inorganic Chemistry Mafenide chemistry.chemical_compound Adsorption law Drug Discovery medicine Physical and Theoretical Chemistry Selectivity medicine.drug
Zdroj:	Helvetica Chimica Acta. 89:1254-1257
ISSN:	1522-2675 0018-019X
Popis:	Both aliphatic and aromatic amino sulfonamides such as mafenide (1a) were synthesized in good yields (80–86%) by direct electrochemical hydrogenation of the corresponding nitriles in an undivided cell containing a Ni cathode, a Pt anode, and Raney Ni as catalyst (Table 1). The reaction can be performed without external supply of pressurized gas by in situ generation of H2. Slightly elevated temperatures (45°) and low current densities (10 mA/cm2) are favorable conditions for this type of electrochemical nitrile hydrogenation. Our synthetic protocol does not require high-pressure equipment or chemical hazards, is environmentally very friendly, and more economical than traditional methods. The concentration of adsorbed H. radicals on the catalyst surface can be easily controlled by adjusting the electric potential, which may lead to improved product selectivity and, at the same time, reduces the risk of explosion and fire.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::5a4bbcd0c82995eb93da51ca36ba1c09 https://doi.org/10.1002/hlca.200690123 Zobrazit plný text záznamu Plný text