pH-Sensitive Polypeptide Conjugated with Carborane Clusters and Cyanine for NIR Bioimaging and Multi-Therapies
| Autor: | Titao Jing, Zheng Ruan, Pan Yuan, Lifeng Yan, Tao Xing |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Materials science
Polymers and Plastics Tertiary amine General Chemical Engineering Organic Chemistry 02 engineering and technology Conjugated system 010402 general chemistry 021001 nanoscience & nanotechnology Photochemistry 01 natural sciences Micelle 0104 chemical sciences chemistry.chemical_compound Cell killing Dynamic light scattering chemistry Materials Chemistry Fluorescence microscope Carborane Cyanine 0210 nano-technology |
| Zdroj: | Macromolecular Research. 26:270-277 |
| ISSN: | 2092-7673 1598-5032 |
| DOI: | 10.1007/s13233-018-6034-z |
| Popis: | A novel pH-sensitive carborane and cyanine dye conjugated polypeptide and its micelles has been designed and synthesized for potential near infrared fluorescence imaging-guided boron neutron capture therapy (BNCT). The amphiphilic polymer we synthesized with tertiary amine as functional group could self-assemble to micelle nanoparticles at neutral pH, and responsive to acidic solution for the disassembly of the micelles for drug release. The tertiary amine sensitive induced process was observed via dynamic light scattering (DLS) and transmission electron microscopy (TEM). The efficiency of cell killing ability is studied by MTT assays and fluorescence microscope measurement, indicating a new intelligent system for potential NIR imaging-guided therapy. |
| Databáze: | OpenAIRE |
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