Synthesis and anticancer activity of some new s-triazine derivatives

Autor:	Shweta Shrivastava, Vegi Ganga Modi Naidu, G. Jagadeesh Kumar, Kolupula Srinivas, H. V. S. Sriramkumar Bomma, E. Srihari, V. Jayathirtha Rao
Rok vydání:	2013
Předmět:	Colorectal cancer Stereochemistry Organic Chemistry medicine.disease In vitro chemistry.chemical_compound Breast cancer chemistry Cancer cell medicine Potency General Pharmacology Toxicology and Pharmaceutics Lung cancer Ovarian cancer Triazine
Zdroj:	Medicinal Chemistry Research. 22:5973-5981
ISSN:	1554-8120 1054-2523
DOI:	10.1007/s00044-013-0584-6
Popis:	New s-triazine derivatives 13a–h were synthesized for the structure–activity relationship studies as potent anticancer agents. The prepared analogues were evaluated for their in vitro inhibitory activity against the growth of PA-1 (Ovarian cancer), A549 (Lung cancer), MCF-7 (Breast cancer), and HT-29 (Colon cancer). Tri-substituted s-triazine derivatives (13e–h) with morpholino group on s-triazine scaffold exhibited potent anticancer activities compared to di-substituted s-triazine derivatives. Compounds 13e–h also showed relatively selective PA-1 and HT-29 cancer cell inhibition over other cancer cell lines. Structure–activity relationships provided useful insights in these classes of compounds and paved the way to design novel analogues with more potency.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::5a43d632a60c746bc2ee740ff74188c2 https://doi.org/10.1007/s00044-013-0584-6 Zobrazit plný text záznamu Full text from SpringerLink