Insulin, Substrate Transport, and Protein Synthesis in Muscle
| Autor: | Peter Rieser, Joseph M. Maturo |
|---|---|
| Rok vydání: | 1969 |
| Předmět: |
chemistry.chemical_classification
medicine.medical_specialty business.industry Insulin medicine.medical_treatment Tryptophan Stimulation Amino acid Cell membrane medicine.anatomical_structure Endocrinology chemistry Biochemistry Internal medicine Insulin receptor substrate Internal Medicine medicine Protein biosynthesis business Hormone |
| Zdroj: | Archives of Internal Medicine. 123:267 |
| ISSN: | 0003-9926 |
| DOI: | 10.1001/archinte.1969.00300130049008 |
| Popis: | Specific labeling by 2-hydroxy-5-nitrobenzyl bromide (HNB) of tryptophan residues in rat diaphragms abolishes insulin stimulation of sugar and amino acid uptake, and of the incorporation of previously accumulated amino acid into muscle protein. A brief period of preincubation of tissues with insulin protects against the antiinsulin effects of the labeling reagent. The proposal is made that tryptophan residues of a polypeptide component in the cell membrane are involved in the recognition of the hormone. Complementary interaction of this component with insulin is regarded as primary to the latter's effects on muscle. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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