Discovery of a Novel Class of Exquisitely Selective Mesenchymal-Epithelial Transition Factor (c-MET) Protein Kinase Inhibitors and Identification of the Clinical Candidate 2-(4-(1-(Quinolin-6-ylmethyl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-6-yl)-1H-pyrazol-1-yl)ethanol (PF-04217903) for the Treatment of Cancer

Autor:	Gilles H. Goetz, Michele McTigue, Max Parker, Ya-Li Deng, Nambu Mitchell David, J. Jean Cui, Shinji Yamazaki, Jia Lei, Neil Grodsky, Shirley A. Aguirre, Jacqui Elizabeth Hoffman, Kevin Ryan, Hong Shen, Phuong Le, Sergei Timofeevski, James G. Christensen, Helen Y. Zou, Cheng Hengmiao, Brion W. Murray, Michelle Tran-Dubé, Mehran Jalaie, Qiuhua Li, Pairish Mason Alan
Rok vydání:	2012
Předmět:	biology Hydrazide medicine.disease_cause Receptor tyrosine kinase chemistry.chemical_compound chemistry Biochemistry Tumor progression Drug Discovery biology.protein medicine Cancer research Molecular Medicine Mesenchymal–epithelial transition Transferase Oxindole Protein kinase A Carcinogenesis
Zdroj:	Journal of Medicinal Chemistry. 55:8091-8109
ISSN:	1520-4804 0022-2623
DOI:	10.1021/jm300967g
Popis:	The c-MET receptor tyrosine kinase is an attractive oncology target because of its critical role in human oncogenesis and tumor progression. An oxindole hydrazide hit 6 was identified during a c-ME...
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::5a253c3b903e7bc7ae29a14c9a9b40dd https://doi.org/10.1021/jm300967g Zobrazit plný text záznamu