Neuronal Ion Channel Signalling Pathways
| Autor: | Craig H. Gelband, Colin Sumners |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Angiotensin receptor
medicine.medical_specialty Angiotensin II receptor type 1 Chemistry Stimulation Cell Biology Angiotensin II Cell biology Endocrinology Internal medicine cardiovascular system medicine Premovement neuronal activity Signal transduction Salt intake Receptor hormones hormone substitutes and hormone antagonists circulatory and respiratory physiology |
| Zdroj: | Cellular Signalling. 10:303-311 |
| ISSN: | 0898-6568 |
| DOI: | 10.1016/s0898-6568(97)00133-2 |
| Popis: | The brain contains both angiotensin II (Ang II) type 1 (AT1) and Ang II type 2 (AT2) receptors. Neuronal AT1 receptors mediate the stimulatory actions of Ang II on blood pressure, water and salt intake, and secretion of vasopressin. In contrast, neuronal AT2 receptors have been implicated in the stimulation of apoptosis and as being antagonistic to AT1 receptors. The physiological actions of Ang II in the brain, whether mediated by AT1 or AT2 receptors, involve changes in neuronal activity that are initiated by changes in the activity of membrane ionic currents and channels. This review focusses on the intracellular signalling pathways that couple neuronal AT1 and AT2 receptors to changes in the activity of membrane K+ and Ca2+ currents and channels. As will become clear from our discussion, the signalling pathways that are modulated by neuronal AT1 and AT2 receptors are quite distinct. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect