Synthesis and Stability of Functionalized Epoxides Topologically Related to β-Lactam Antibiotics

Autor:	Léon Ghosez, Didier Ferroud, Jacqueline Marchand-Brynaert, B. Serckx‐Poncin
Rok vydání:	2010
Předmět:	Stereochemistry Chemistry General Chemistry Ring (chemistry) Antibacterial activity Beta lactam antibiotics
Zdroj:	Bulletin des Sociétés Chimiques Belges. 99:1075-1084
ISSN:	0037-9646
DOI:	10.1002/bscb.19900991126
Popis:	Epoxides 3-4 topologically related to penicillins and oxamazins have been designed as potential alkylating inhibitors of bacterial D, D-peptidases. A series of N-acylated olefins 17-19 and 22 have been prepared. It was found that the corresponding epoxides bearing a free carboxyl group were unstable. Neither the olefinic precursors nor the lactones 23 resulting from ring opening of the epoxides 4 exhibited any antibacterial activity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::5a20b3ab24a352247c6d87641a12def5 https://doi.org/10.1002/bscb.19900991126 Zobrazit plný text záznamu